HENRY M. SOBELL
A MECHANISM TO UNDERSTAND THE B- TO Z- TRANSITION
The B- to Z- transition arises as the result of a bifurcation that takes place during the formation of the dislocaton. A fundamental prediction of the model is the appearance of single-stranded DNA regions juxtaposed to beta-DNA regions within each B-Z junction. The model predicts S1 nuclease sensitive sites to lie within the junctions, and predicts high cooperatively to accompany ethidium binding. Both predictions are supported by experimental data. See text for additional discussion.